Key progress in key technologies for freeze-drying

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After four years of research and development, Bo Medical has successfully developed a new generation of intelligent pilot vacuum freeze dryers. This technology belongs to the international frontier of freeze-drying technology, a number of independent innovation technologies, expanding the application and promotion scope of vacuum freeze-drying.

Freeze-drying process is a complex process of heat and mass transfer, involving refrigeration, vacuum, electrical, heat transfer, thermodynamics, mechanical engineering, ultra-low temperature technology and other disciplines, high technical content, freeze-dried process is complex. With the increasingly widespread application of freeze-drying technology in many fields such as pharmaceutical production, bio-engineering, scientific research, food and health product production, cultural relics and archaeology, users have higher and higher requirements for their process fitting and intelligence.

China's product development for freeze dryers began in the 1980s. At present, there are more than 10 manufacturers. Most manufacturers are only in the state of satisfying the most basic freeze-drying requirements. The overall technical level of the industry is always at a low level. The first-rate foreign products have excellent performance and are expensive, and they cannot meet the needs of a wider range of users. The development of a new generation of intelligent freeze dryers is a requirement of China's national conditions. Beijing Bo Medical has jointly developed a new generation of intelligent vacuum freeze dryers based on its own resources and a number of experts in the industry.

There are three series of hundreds of products in the new generation of intelligent vacuum freeze-drying machines, which are specifically:

Lab Series Applications:

1. The degree of vacuum needs to be adjusted during lyophilization.

2. Sublimation and analytical drying require temperature control.

3. A higher ultimate vacuum is required during lyophilization.

4. Automatic defrosting, automatic drainage function.

5. Freeze-drying data and curve search function.

6. Pulsation backfill after lyophilization.

7. The product eutectic point and eutectic point temperature are not lower than -20°C.

8. Deliquescence occurs during the establishment of a vacuum in the trace sample.

9.Lab series process optimization rate can reach 30%.

The Pilot1-2LD/Pilot1-2MD/Pilot2-4LD/Pilot2-4MD models are suitable for laboratory pilot tests. This series proposes solutions for the following problems.

1. After the product is pre-frozen, deliquescence occurs during transfer.

2. Trace samples deliquescence during the establishment of a vacuum.

3. The pre-freezing temperature needs to be adjusted during the pre-freezing of the sample.

4. Sample analysis requires a lower vacuum during drying.

5. Meet the laboratory requirements of full-featured and relatively small-footprint vacuum freeze dryer requirements.

6. The process optimization rate is 40-70%.

The Pilot series is suitable for small-scale and pilot-scale production and is suitable for the exploration and optimization of production processes for industrial materials, foods and health products (up to 65% process optimization rate).

The Pilot series of standard models are suitable for small-scale testing and pilot-scale R&D of pharmaceuticals and biological agents. Users can choose to use wall insulation and non-wall insulation according to the cleanliness requirements. The process optimization rate of this series of models can reach more than 90%, fully satisfying GMP and FDA requirements.

The LYO series is mainly used for freeze-drying production. The basic type, CIP type and SIP type can be selected according to user requirements. Applications include freeze-drying of chemicals, biological drugs, biological agents, Chinese medicines, health products, high-grade foods, spices, feed additives, and industrial special applications.

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